Article

Impaired BCAA catabolism during adipocyte differentiation decreases glycolytic flux

2022-05-29

Abstract excerpt

Dysregulated branched chain amino acid (BCAA) metabolism has emerged as a key metabolic feature associated with the obese insulin resistant state, and adipose BCAA catabolism is decreased in this context. BCAA catabolism is upregulated early in adipogenesis, but the impact of suppressing this pathway on the broader metabolic functions of the resultant adipocyte remain unclear. Here, we use CRISPR/Cas9 to target B...

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Literature Corpus work: 14052cdd-c944-5542-adac-288df29f0e65
DOI: 10.1101/2022.05.27.493780

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