Article

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

2024-07-02

Abstract excerpt

Spatial RNA imaging has not been widely adopted because conventional fluorescence microscopy is limited to only a few channels, and the cyclic reactions needed to increase multiplexing in techniques such as sequential fluorescence in-situ hybridization (FISH) require sophisticated instrumentation. Here, we introduce ‘Profiling of RNA In-situ through Single-round iMaging’ (PRISM), a method that expands coding capac...

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Literature Corpus work: 6d64b545-ff92-52a4-9837-d4eedb7d9997
DOI: 10.1101/2024.06.29.601330

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