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Spatial transcriptomics for profiling the tropism of viral vectors in tissues

26 Jan 2023

Abstract excerpt

A barrier to advancing engineered adeno-associated viral vectors (AAVs) for precision access to cell subtypes is a lack of high-throughput, high-resolution assays to characterize in vivo transduction profiles. In this study, we developed an ultrasensitive, sequential fluorescence in situ hybridization (USeqFISH) method for spatial transcriptomic profiling of endogenous and viral RNA with a short barcode in intact...

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PMID: 36702899
DOI: 10.1038/s41587-022-01648-w

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