Article

Cross-linked volumetric DNA microscopy for dense molecular-network phenotyping in intact tissue

2026-06-04

Abstract excerpt

Resolving cellular phenotypes in full tissue context requires methods that can retain those cells’ physical neighborhoods, together with the identities of individual biomolecules, in intact three-dimensional specimens. We introduce cross-linked volumetric DNA microscopy (xVDM), in which unique molecular identifiers are seeded directly into the tissue’s protein matrix and linked by uniquely labeled DNA bridges to c...

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Literature Corpus work: b2c86596-e310-5a3b-8130-b54a16acbd96
DOI: 10.64898/2026.06.01.729154

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