Polymorphism in the P-glycoprotein drug transporter MDR1 gene

Abstract excerpt

P-glycoprotein is a membrane protein encoded by theMDR1gene, which demonstrates functional polymorphism. It is present in endothelial cells of the blood-brain barrier, thus limiting accumulation of its substrates in the central nervous system. Many epidemiological studies suggest an association between pesticides, which are substrates for P-glycoprotein, and Parkinson's disease. It was hypothesized that polymorphi...

Topics

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• Drug Transport and Resistance Mechanisms
• Hemoglobinopathies and Related Disorders
• Pharmacological Effects and Toxicity Studies

Identifiers and source

Literature Corpus work

6d3e3003-cf41-57d0-aa5a-063d53ff70f1

DOI

10.1097/00008571-200305000-00004