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Article

MDR1 C3435T polymorphism and interaction with environmental factors in risk of Parkinson's disease: a case-control study in Japan.

Drug metabolism and pharmacokinetics - 1 Jan 2013

Kiyohara Chikako, Miyake Yoshihiro, Koyanagi Midori, Fujimoto Takahiro, Shirasawa Senji, Tanaka Keiko, Fukushima Wakaba, Sasaki Satoshi, Tsuboi Yoshio, Yamada Tatsuo, Oeda Tomoko, Shimada Hiroyuki, Kawamura Nobutoshi, Sakae Nobutaka, Fukuyama Hidenao, Hirota Yishio, Nagai Masaki

Abstract excerpt

It has been suggested that P-glycoprotein (P-gp), the product of multidrug resistance 1 (MDR1) gene, regulates the brain entry of various xenobiotics. Impaired function of P-gp may be associated with an increased risk of Parkinson's disease (PD). The aim of this study was to investigate the impact of a MDR1 C3435T polymorphism on PD risk alone or in combination with environmental factors. A total of 238 patients...

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Identifiers

PMID: 22971641
DOI: 10.2133/dmpk.dmpk-12-rg-075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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