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Article

Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease.

Pharmacogenetics - 1 Oct 2002

Furuno Taku, Landi Maria-Teresa, Ceroni Mauro, Caporaso Neil, Bernucci Ilaria, Nappi Giuseppe, Martignoni Emilia, Schaeffeler Elke, Eichelbaum Michel, Schwab Matthias, Zanger Ulrich M

Abstract excerpt

Because drug transporters such as P-glycoprotein, the product of the multidrug resistance (MDR1 ) gene, contribute to the function of the blood-brain barrier, we hypothesized that differences in their expression could affect the uptake of neurotoxic xenobiotics, thereby modulating interindividual susceptibility for neurological disorders such as Parkinson's disease. In a pilot case-control study comprising 95...

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PMID: 12360103
DOI: 10.1097/00008571-200210000-00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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