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Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease.

Pharmacogenetics - 1 May 2003

Droździk Marek, Białecka Monika, Myśliwiec Katarzyna, Honczarenko Krystyna, Stankiewicz Jan, Sych Zbigniew

Abstract excerpt

P-glycoprotein is a membrane protein encoded by the MDR1 gene, which demonstrates functional polymorphism. It is present in endothelial cells of the blood-brain barrier, thus limiting accumulation of its substrates in the central nervous system. Many epidemiological studies suggest an association between pesticides, which are substrates for P-glycoprotein, and Parkinson's disease. It was hypothesized that...

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PMID: 12724617
DOI: 10.1097/01.fpc.0000054087.48725.d9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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