Article

Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation

2023-11-08

Abstract excerpt

Prominin-1 (Prom1) is a five-transmembrane-pass integral membrane protein that associates with curved regions of the plasma membrane. Prom1 interacts with membrane cholesterol and actively remodels the plasma membrane. Membrane bending activity is particularly evident in photoreceptors, where Prom1 loss-of-function mutations cause failure of outer segment homeostasis, leading to cone-rod retinal dystrophy (CRRD)....

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Literature Corpus work: 6d2fd86c-4fbe-57ba-8a84-643d21f1f90d
DOI: 10.1101/2023.11.08.566258

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