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Article

Distinct roles for prominin-1 and photoreceptor cadherin in outer segment disc morphogenesis in CRISPR-altered X. laevis

1 Jan 2020

Abstract excerpt

Mutations in prominin-1 (prom1) and photoreceptor cadherin (cdhr1) are associated with inherited retinal degenerative disorders but their functions remain unknown. We used CRISPR-Cas9 to generate prom1-, cdhr1-, and prom1+cdhr1-null X. laevis and then documented the effects of these mutations on photoreceptor structure and function. Prom1-null mutations resulted in severely dysmorphic photoreceptors comprised of...

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PMID: 33277376
DOI: 10.1242/jcs.253906

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Distinct roles for prominin-1 and photoreceptor cadherin in outer segment disc morphogenesis in CRISPR-altered X. laevisPMID 33277376Read ↗

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