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Article

The Role of Peripherin-2/ROM1 Complexes in Photoreceptor Outer Segment Disc Morphogenesis.

Advances in experimental medicine and biology - 1 Jan 2023

Lewis Tylor R, Al-Ubaidi Muayyad R, Naash Muna I, Arshavsky Vadim Y

Abstract excerpt

The light-sensitive outer segment organelle of photoreceptor cells contains a stack of hundreds of flat, disc-shaped membranes called discs. The rims of these discs contain a photoreceptor-specific tetraspanin protein peripherin-2 (also known as rds or PRPH2). Mutations in the PRPH2 gene lead to a wide variety of inherited retinal degenerations in humans. The vast majority of these mutations occur within a large,...

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Identifiers

PMID: 37440045
DOI: 10.1007/978-3-031-27681-1_40

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Role of Peripherin-2/ROM1 Complexes in Photoreceptor Outer Segment Disc Morphogenesis.PMID 37440045Read ↗

The Interplay between Peripherin 2 Complex Formation and Degenerative Retinal Diseases.Semantic proximity Read ↗

PRPH2/RDS and ROM-1: Historical context, current views and future considerations.Semantic proximity Read ↗

ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims.Semantic proximity Read ↗

Photoreceptor Disc Enclosure Is Tightly Controlled by Peripherin-2 Oligomerization.Semantic proximity Read ↗

Oligomerization of Prph2 and Rom1 is essential for photoreceptor outer segment formation.Semantic proximity Read ↗

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.Semantic proximity Read ↗

Photoreceptor outer segment disk rim curvature relies on a tetraspanin interaction webSemantic proximity Read ↗

Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization.Semantic proximity Read ↗

Multistep peripherin-2/rds self-assembly drives membrane curvature for outer segment disk architecture and photoreceptor viabilitySemantic proximity Read ↗

Role of peripherin/rds in vertebrate photoreceptor architecture and inherited retinal degenerations.Semantic proximity Read ↗

Peripherin/rds Influences Membrane Vesicle MorphologySemantic proximity Read ↗

Role of the Second Intradiscal Loop of Peripherin/<i>rds </i>in Homo and Hetero AssociationsSemantic proximity Read ↗

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