Article

Photoreceptor outer segment disk rim curvature relies on a tetraspanin interaction web

2026-05-04

Abstract excerpt

Rod and cone photoreceptors are sensory neurons required for the first steps of image-forming vision. Mutations in PRPH2 damage photoreceptor viability and produce a broad range of inherited retinal degenerations (IRDs) for which no treatments are available. The gene product, PRPH2 (peripherin-2), is an integral membrane tetraspanin that is required for the biogenesis and normal structure of photoreceptor outer s...

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Literature Corpus work: ad04cc6c-f6ca-582e-96b9-81d67e2fa8d9
DOI: 10.64898/2026.04.29.721402

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