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Article

Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Feb 2009

Zacchigna Serena, Oh Hideyasu, Wilsch-Bräuninger Michaela, Missol-Kolka Ewa, Jászai József, Jansen Sandra, Tanimoto Naoyuki, Tonagel Felix, Seeliger Mathias, Huttner Wieland B, Corbeil Denis, Dewerchin Mieke, Vinckier Stefan, Moons Lieve, Carmeliet Peter

Abstract excerpt

Prominin-1/CD133 (Prom-1) is a commonly used marker of neuronal, vascular, hematopoietic and other stem cells, yet little is known about its biological role and importance in vivo. Here, we show that loss of Prom-1 results in progressive degeneration of mature photoreceptors with complete loss of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19228982
DOI: 10.1523/JNEUROSCI.2034-08.2009
PMCID: PMC6666336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19228982-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration.PMID 19228982Read ↗

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