Article
The membrane curvature-inducing REEP1-4 proteins generate an ER-derived vesicular compartment.
Nature communications - 5 Oct 2024
Shibata Yoko, Mazur Emily E, Pan Buyan, Paulo Joao A, Gygi Steven P, Chavan Suyog, Valerio L Sebastian Alexis, Zhang Jiuchun, Rapoport Tom A
Abstract excerpt
The endoplasmic reticulum (ER) is shaped by abundant membrane curvature-generating proteins that include the REEP family member REEP5. The REEP1 subfamily, consisting of four proteins in mammals (REEP1-4), is less abundant and lack a N-terminal region. Mutations in REEP1 and REEP2 cause Hereditary Spastic Paraplegia, but the function of these four REEP proteins remains enigmatic. Here we show that REEP1-4 reside...
Topics
- Endoplasmic Reticulum
- Membrane Proteins
- Humans
- Animals
- Mutation
- Spastic Paraplegia, Hereditary
- HEK293 Cells
- HeLa Cells
- Membrane Transport Proteins
- Mice
- GTP-Binding Proteins