Back to search

Article

Prominin-1 and Macular Dystrophy: Expanding the Biology From Photoreceptors to the Retinal Pigment Epithelium

2026-03-12

Abstract excerpt

Prominin-1 (Prom1/CD133) has long been recognized as a structural determinant of photoreceptor outer segment (OS) morphogenesis, yet rapidly accumulating evidence extends its role to retinal pigment epithelium (RPE) homeostasis, encompassing autophagy–lysosomal flux, outer segment phagocytosis, mitochondrial function, and regulation of inflammatory stress. This review synthesizes mechanistic and transcriptomic ins...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1a08a27c-cc22-5dba-bf9d-858d6a7a3b1c
DOI
10.20944/preprints202603.0984.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Prominin-1 and Macular Dystrophy: Expanding the Biology From Photoreceptors to the Retinal Pigment EpitheliumDOI 10.20944/preprints202603.0984.v1
Prominin-1 Regulates Retinal Pigment Epithelium Homeostasis: Transcriptomic Insights into Degenerative MechanismsSemantic proximity
Prominin-1 Knockdown Causes RPE Degeneration in a Mouse ModelSemantic proximity
Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration.Semantic proximity
Exogenous photoreceptor-specific N-glycosylated PROM1 rescues retinal degeneration in patient and mouse models.Semantic proximity
Deciphering the Impact of PROM1 Alternative Splicing on Human Photoreceptor Development and MaturationSemantic proximity
Loss of Prom1 impairs autophagy and promotes epithelial‐mesenchymal transition in mouse retinal pigment epithelial cellsSemantic proximity
Retinal Organoid Single-Cell Transcriptomics Reveals Effects of PRPF31 Mutation on Early Müller Glial Activation and Progressive Photoreceptor DegenerationSemantic proximity
Exogenous Photoreceptor-Specific N-Glycosylated PROM1 Rescues Retinal Degeneration in Patient and Mouse ModelsSemantic proximity
Clinical and Molecular Characterization of PROM1 -Related Retinal DegenerationSemantic proximity
Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degenerationSemantic proximity
Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in miceSemantic proximity
Single Cell Transcriptomics on PRPF31 Retinal Organoids Reveal Early Müller Glial Activation and Progressive Photoreceptor DegenerationSemantic proximity
Select a neighboring publication to make it the new centre.