Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3.

The Journal of biological chemistry - 1 May 2020

Jászai József, Thamm Kristina, Karbanová Jana, Janich Peggy, Fargeas Christine A, Huttner Wieland B, Corbeil Denis

Abstract excerpt

Prominins (proms) are transmembrane glycoproteins conserved throughout the animal kingdom. They are associated with plasma membrane protrusions, such as primary cilia, as well as extracellular vesicles derived thereof. Primary cilia host numerous signaling pathways affected in diseases known as ciliopathies. Human PROM1 (CD133) is detected in both somatic and cancer stem cells and is also expressed in terminally...

Topics

Join the communities discussing this publication.

AC133 Antigen
Cilia
Down-Regulation
Intracellular Space
Kupffer Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Madin Darby Canine Kidney Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 32201384
DOI: 10.1074/jbc.RA119.011253
PMCID: PMC7196652

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3.PMID 32201384Read ↗

Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epitheliumSemantic proximity Read ↗

A frameshift mutation in prominin (mouse)-like 1 causes human retinal degenerationSemantic proximity Read ↗

Prominin-1 and Macular Dystrophy: Expanding the Biology From Photoreceptors to the Retinal Pigment EpitheliumSemantic proximity Read ↗

Deletion of the transmembrane protein Prom1b in zebrafish disrupts outer-segment morphogenesis and causes photoreceptor degenerationSemantic proximity Read ↗

Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration.Semantic proximity Read ↗

Cross species analysis of Prominin reveals a conserved cellular role in invertebrate and vertebrate photoreceptor cells.Semantic proximity Read ↗

Prom1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epitheliumSemantic proximity Read ↗

Exogenous photoreceptor-specific N-glycosylated PROM1 rescues retinal degeneration in patient and mouse models.Semantic proximity Read ↗

Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in miceSemantic proximity Read ↗

Prominin-1 Regulates Retinal Pigment Epithelium Homeostasis: Transcriptomic Insights into Degenerative MechanismsSemantic proximity Read ↗

Characterization of Prominin-2, a New Member of the Prominin Family of Pentaspan Membrane GlycoproteinsSemantic proximity Read ↗

Systematic discovery of novel ciliary genes through functional genomics in the zebrafish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.