Gating mechanism of the human α1β GlyR by glycine

Abstract excerpt

Glycine receptors (GlyRs) are members of the Cys-loop receptors that constitute a major portion of neurotransmitter receptors in the human nervous system. GlyRs are found in the spinal cord and brain mediating locomotive, sensory and cognitive functions, and are targets for pharmaceutical development. GlyRs share a general gating scheme with Cys-loop receptor family members, but the underlying mechanism is unclear...

Topics

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• Binding Sites
• Glycine
• Ion Channel Gating
• Models, Molecular
• Mutation
• Neurotransmitter Agents
• Protein Conformation
• Receptors, Glycine

Identifiers and source

Literature Corpus work

bbe38a93-15e0-5a54-b81f-47028c82b863

DOI

10.1101/2023.08.08.552474