Article

Natural Selection at an Exceptionally Long GGC Repeat in the Human RASGEF1C and Divergent Genotypes in Late-onset Neurocognitive Disorder

2021-05-17

Abstract excerpt

Across the human protein-coding genes, the neuron-specific gene, RASGEF1C , contains the longest (GGC)-repeat, spanning its core promoter and 5′ untranslated region (RASGEF1C-201 ENST00000361132.9). RASGEF1C expression dysregulation occurs in late-onset neurocognitive disorders (NCDs), such as Alzheimer’s disease. Here we sequenced the GGC-repeat in a sample of human subjects (N = 269), consisting of late-onset NC...

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Literature Corpus work: 6d110c01-aa27-5af0-9728-c47955a575d6
DOI: 10.21203/rs.3.rs-517583/v1

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