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Article

Natural selection at the RASGEF1C (GGC) repeat in human and divergent genotypes in late-onset neurocognitive disorder.

Scientific reports - 28 Sept 2021

Jafarian Z, Khamse S, Afshar H, Khorshid H R Khorram, Delbari A, Ohadi M

Abstract excerpt

Expression dysregulation of the neuron-specific gene, RASGEF1C (RasGEF Domain Family Member 1C), occurs in late-onset neurocognitive disorders (NCDs), such as Alzheimer's disease. This gene contains a (GGC)13, spanning its core promoter and 5' untranslated region (RASGEF1C-201 ENST00000361132.9). Here we sequenced the (GGC)-repeat in a sample of human subjects (N = 269), consisting of late-onset NCDs (N = 115)...

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PMID: 34584172
DOI: 10.1038/s41598-021-98725-y
PMCID: PMC8479062

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