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Natural Selection at the NHLH2 Core Promoter Exceptionally Long CA-Repeat in Human and Disease-Only Genotypes in Late-Onset Neurocognitive Disorder.

Gerontology - 1 Jan 2020

Afshar Hossein, Adelirad Fatemeh, Kowsari Ali, Kalhor Naser, Delbari Ahmad, Najafipour Reza, Foroughan Mahshid, Bozorgmehr Ali, Khamse Safoura, Nazaripanah Neda, Ohadi Mina

Abstract excerpt

BACKGROUND: Approximately 2% of the human core promoter short tandem repeats (STRs) reach lengths of ≥6 repeats, which may in part be a result of adaptive evolutionary processes and natural selection. A single-exon transcript of the human nescient helix loop helix 2 (NHLH2) gene is flanked by the longest CA-repeat detected in a human protein-coding gene core promoter (Ensembl transcript ID: ENST00000369506.1)....

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Share to Aged, 80 and over
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32877896
DOI: 10.1159/000509471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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