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Article

Novel implications of a strictly monomorphic (GCC) repeat in the human PRKACB gene.

Scientific reports - 19 Oct 2021

Khamse Safoura, Jafarian Zahra, Bozorgmehr Ali, Tavakoli Mostafa, Afshar Hossein, Keshavarz Maryam, Moayedi Razieh, Ohadi Mina

Abstract excerpt

PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta) is predominantly expressed in the brain, and regulation of this gene links to neuroprotective effects against tau and Aβ-induced toxicity. Here we studied a (GCC)-repeat spanning the core promoter and 5' UTR of this gene in 300 human subjects, consisting of late-onset neurocognitive disorder (NCD) (N = 150) and controls (N = 150). We also implemented...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34667254
DOI: 10.1038/s41598-021-99932-3
PMCID: PMC8526596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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