Article

Novel biological implication of a strictly monomorphic GCC repeat in the human PRKACB gene

2021-04-21

Abstract excerpt

Across human protein-coding genes, PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta) contains one of the longest GCC-repeats, and is predominantly expressed in the brain. Here we studied this STR in 300 human subjects, consisting of late-onset neurocognitive disorder (NCD) (N = 150) and controls (N = 150). We also studied the impact of this STR on the three-dimensional structure of DNA. While the PRKAC...

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Literature Corpus work: e194cf9c-786a-5065-894b-9451b8faa41a
DOI: 10.21203/rs.3.rs-428458/v1

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