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Human Papillomavirus-driven repression of NRF2 signaling confers chemosensitivity and predicts prognosis in head and neck squamous cell carcinoma

2022-06-10

Abstract excerpt

<h4>Purpose: </h4> To investigate the role of NRF2 signaling in conferring superior prognosis in patients with HPV positive (HPV + ve ) head & neck squamous cell carcinomas (HNSCC) compared to HPV negative (HPV − ve ) HNSCC and develop molecular markers for selection of HPV + ve HNSCC patients for treatment de-escalation trials. Methods We compared NRF2 activity ( NRF2 , KEAP1 , and NRF2-transcriptional targets),...

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Literature Corpus work
6cf22349-201d-5435-a098-94b0f6e76c7c
DOI
10.21203/rs.3.rs-1733748/v1
Open publication

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Human Papillomavirus-driven repression of NRF2 signaling confers chemosensitivity and predicts prognosis in head and neck squamous cell carcinomaDOI 10.21203/rs.3.rs-1733748/v1
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