Article

HPV status and oxygen tension shape transcriptomic, inflammatory, and cell cycle responses in HNSCC treated with ionizing radiation

2025-10-27

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) comprises biologically distinct subtypes defined by human papillomavirus (HPV) status, which may influence treatment outcomes. Hypoxia is a common feature of solid tumors, including HNSCC, and can reduce radiotherapy efficacy by modulating DNA repair, cell-cycle progression, and inflammatory signaling. However, the combined impact of hypoxia and HPV status on cellular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff9f79d2-6f17-5a80-9741-671bc21d3b57
DOI: 10.1101/2025.10.26.684626

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HPV status and oxygen tension shape transcriptomic, inflammatory, and cell cycle responses in HNSCC treated with ionizing radiationDOI 10.1101/2025.10.26.684626Read

Molecular Aspects of Head and Neck Cancer Therapy.Semantic proximity Read

Genotyping and Characterization of HPV Status, Hypoxia, and Radiosensitivity in 22 Head and Neck Cancer Cell LinesSemantic proximity Read

Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV SubtypesSemantic proximity Read

A highly resolved integrated single-cell atlas of HPV-negative head and neck cancerSemantic proximity Read

Contributions of viral oncogenes of HPV-18 and hypoxia to oxidative stress and genetic damage in human keratinocytesSemantic proximity Read

Targeting cellular and molecular drivers of head and neck squamous cell carcinoma: current options and emerging perspectives.Semantic proximity Read

A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypesSemantic proximity Read

Hypoxia induces radioresistance, epithelial‑mesenchymal transition, cancer stem cell‑like phenotype and changes in genes possessing multiple biological functions in head and neck squamous cell carcinoma.Semantic proximity Read

Hypoxia Modulates Radiosensitivity and Response to Different Radiation Qualities in A549 Non-Small Cell Lung Cancer (NSCLC) CellsSemantic proximity Read

Molecular pathology of head and neck cancer.Semantic proximity Read

Tumor microenvironment governs the prognostic landscape of immunotherapy for head and neck squamous cell carcinoma: A computational model-guided analysisSemantic proximity Read

Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancerSemantic proximity Read