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NRF2 signaling is repressed in HPV-driven head and neck cancer and correlates with better prognosis: HPV-E6/E7 confers chemosensitivity by inhibiting NRF2

2022-04-05

Abstract excerpt

<h4>Background: </h4> To investigate the role of NRF2 signaling in conferring superior prognosis in patients with HPV positive (HPV +ve ) head & neck squamous cell carcinomas (HNSCC) compared to HPV negative (HPV -ve ) HNSCC and develop molecular markers for selection of HPV +ve HNSCC patients for treatment de-escalation trials. <h4>Methods: </h4>: We compared NRF2 activity ( NRF2 , KEAP1 , and NRF2-transcriptiona...

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Literature Corpus work
1ce761b4-5c1f-517e-99ba-51557ce8eb1b
DOI
10.21203/rs.3.rs-1504099/v1
Open publication

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NRF2 signaling is repressed in HPV-driven head and neck cancer and correlates with better prognosis: HPV-E6/E7 confers chemosensitivity by inhibiting NRF2DOI 10.21203/rs.3.rs-1504099/v1
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