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Article

HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell-Like Phenotype in Head and Neck Squamous Cell Carcinoma.

Cancer research - 15 Oct 2025

Roy Souvick, Miyauchi Sayuri, Jones Riley N, Kim Sangwoo S, Venuti Aldo, Boparai Angad S, Mell Loren K, Guo Theresa, Califano Joseph A, Sharabi Andrew B

Abstract excerpt

Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HPV+ HNSCC) is one of the most rapidly increasing cancers in the United States. Although patients with HPV+ HNSCC exhibit better responses to chemoradiation compared with patients with HPV- HNSCC, a subset still develops recurrent/refractory disease. In this study, we investigated the role and mechanisms by which the HPV E5 oncogene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40838991
DOI: 10.1158/0008-5472.CAN-24-3989

Genes

SOX9
SOX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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