Article

Human papilloma virus E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis

2022-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Therapy with radiation plus cisplatin kills human papilloma virus-related (HPV+) oropharyngeal squamous cell carcinomas (OPSCCs) by increasing reactive oxygen species beyond cellular antioxidant capacity. To explore why some patients fail these standard treatments, we evaluated whether the variation in HPV oncoprotein levels among HPV+ OPSCCs impacts mitochondrial metabolism, a source of antioxi...

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Literature Corpus work: dfea4e6b-97e5-5bbf-84b5-9d1f84f000f0
DOI: 10.1101/2022.05.04.490169

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Human papilloma virus E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axisDOI 10.1101/2022.05.04.490169Read

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