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Article

ARID1A loss is associated with increased NRF2 signaling in human head and neck squamous cell carcinomas.

PloS one - 1 Jan 2024

Nguyen Vinh, Schrank Travis P, Major Michael B, Weissman Bernard E

Abstract excerpt

Prior to the next generation sequencing and characterization of the tumor genome landscape, mutations in the SWI/SNF chromatin remodeling complex and the KEAP1-NRF2 signaling pathway were underappreciated. While these two classes of mutations appeared to independently contribute to tumor development, recent reports have demonstrated a mechanistic link between these two regulatory mechanisms in specific cancer...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 38358974
DOI: 10.1371/journal.pone.0297741
PMCID: PMC10868765

Genes

ARID1A
KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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