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Article

Animal models of psychiatric disorders that reflect human copy number variation.

Neural plasticity - 1 Jan 2012

Nomura Jun, Takumi Toru

Abstract excerpt

The development of genetic technologies has led to the identification of several copy number variations (CNVs) in the human genome. Genome rearrangements affect dosage-sensitive gene expression in normal brain development. There is strong evidence associating human psychiatric disorders, especially autism spectrum disorders (ASDs) and schizophrenia to genetic risk factors and accumulated CNV risk loci. Deletions...

Topics

Animals
Chromosomes, Mammalian
DNA Copy Number Variations
Disease Models, Animal
Gene Deletion
Gene Duplication
Genetic Engineering
Genetic Predisposition to Disease
Humans
Mental Disorders
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Schizophrenia

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Identifiers

PMID: 22900207
DOI: 10.1155/2012/589524
PMCID: PMC3414062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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