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Single-cell analysis of human basal cell carcinoma reveals novel regulators of tumor growth and the tumor microenvironment

10 Jun 2022

Abstract excerpt

How basal cell carcinoma (BCC) interacts with its tumor microenvironment to promote growth is unclear. We use singe-cell RNA sequencing to define the human BCC ecosystem and discriminate between normal and malignant epithelial cells. We identify spatial biomarkers of tumors and their surrounding stroma that reinforce the heterogeneity of each tissue type. Combining pseudotime, RNA velocity-PAGA, cellular entropy,...

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PMID: 35687691
DOI: 10.1126/sciadv.abm7981

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