Article

Integrating trajectory inference and gene regulatory network analysis to resolve transcriptional programs of T cell state transitions in the tumor microenvironment

2026-05-14

Abstract excerpt

Reconstructing dynamic immune cell state transitions from single-cell transcriptomic data requires coordinated analytical strategies that capture both phenotypic progression and underlying regulatory programs. This protocol describes a step-by-step computational workflow for analyzing human tumor-infiltrating T cells using the sequential application of dimensionality reduction, pseudotime trajectory inference, reg...

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Literature Corpus work: 162bd6e8-cc98-59c3-9b5f-6e9d2ed05b4e
DOI: 10.64898/2026.05.12.724558

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