Article

Computationally Guided Design of Dipeptidyl Peptidase-4 Inhibitors

2019-09-18

Abstract excerpt

<h4>ABSTRACT</h4> The Type 2 Diabetes Mellitus (T2DM) epidemic undoubtedly creates a need for the development of new pharmaceuticals. With the goal of generating new therapeutics for this disease, computational studies were conducted to design novel dipeptidyl peptidase-4 (DPP-4) inhibitors. Two candidates, generated by chemical intuition-driven design and bioisosteric replacement, were found to have better docki...

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Literature Corpus work: 6cd3b8d9-9296-50e8-8ca2-353e5de55ef8
DOI: 10.1101/772137

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