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Computational Identification of Natural Product-Derived GSK-3β Inhibitors as Candidate Therapeutics for Type 2 Diabetes and MASH

2026-06-05

Abstract excerpt

<title>Abstract</title> <p>Background Type 2 Diabetes Mellitus (T2DM) and Metabolic Dysfunction-Associated Steatohepatitis (MASH) represent two converging metabolic epidemics that share interconnected pathophysiological mechanisms. Glycogen synthase kinase-3 beta (GSK-3β) is a master metabolic regulator whose sustained hyperactivation drives both diseases, making it an attractive therapeutic target for both cond...

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Literature Corpus work
036e3da7-8be6-55f4-9f04-411b7cce69e5
DOI
10.21203/rs.3.rs-9763432/v1
Open publication

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Computational Identification of Natural Product-Derived GSK-3β Inhibitors as Candidate Therapeutics for Type 2 Diabetes and MASHDOI 10.21203/rs.3.rs-9763432/v1
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