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Structure-Based Virtual Screening and Discovery of Novel Thiazole Derivatives as Potential PPARγ Modulators for Type 2 Diabetes Mellitus

2026-03-06

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<title>Abstract</title> <p> <bold>Introduction:</bold> Type 2 diabetes mellitus (T2DM) is a major metabolic disorder marked by insulin resistance and impaired β-cell function. Peroxisome proliferator-activated receptor gamma (PPARγ) serves as a key nuclear receptor regulating glucose and lipid metabolism. While thiazolidinedione (TZD) drugs effectively activate PPARγ, their clinical use is restricted due to adv...

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Literature Corpus work
b1fca24d-21df-5a7b-b234-35c1f1ec8dc0
DOI
10.21203/rs.3.rs-8894257/v1
Open publication

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