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Molecular docking studies and molecular dynamic simulation analysis: To identify novel ATP-competitive inhibition of Glycogen synthase kinase-3β for Alzheimer’s disease

2025-05-27

Abstract excerpt

<h4>Background: </h4> The discovery of an ideal and effective therapy is urgently required for the treatment of Alzheimer’s disease (AD). The main pathological hallmarks of Alzheimer’s disease that appear before the clinical symptoms are neurofibrillary tangles, amyloid plaques, brain inflammation, and neuronal atrophy throughout the cerebral cortex and hippocampus. GSK-3β (Glycogen Synthase Kinase-3β) is regarded...

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Literature Corpus work: 7e1a1a10-f9d9-550f-bf71-bf60d922509c
DOI: 10.12688/f1000research.145391.3

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