Article

Normal Uterine Fibroblast Are Reprogramed into Ovarian Cancer-Associated Fibroblasts by Ovarian Tumor-derived Conditioned Media

2023-10-02

Abstract excerpt

<h4>SUMMARY</h4> Cancer-associated fibroblasts (CAFs) are key contributors to ovarian cancer (OC) progression and therapeutic resistance through dysregulation of the extracellular matrix (ECM). CAFs are a heterogenous population derived from different cell types through activation and reprogramming. Current studies rely on uncharacterized heterogenous primary CAFs or normal fibroblasts that fail to recapitulate C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cb13e3c-3c8d-54fa-8b3c-8b4251a2c3c5
DOI: 10.1101/2023.09.29.560158

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Normal Uterine Fibroblast Are Reprogramed into Ovarian Cancer-Associated Fibroblasts by Ovarian Tumor-derived Conditioned MediaDOI 10.1101/2023.09.29.560158Read

Reprogramming of normal fibroblasts into ovarian cancer-associated fibroblasts via non-vesicular paracrine signaling induces an activated fibroblast phenotype.Semantic proximity Read

Functional consistency and molecular evolution: a comprehensive characterization of primary endometrial cancer-associated fibroblasts during in vitro expansion.Semantic proximity Read

Dissecting endometrial cancer complexity in response to standard and targeted therapiesSemantic proximity Read

Diversity and Biology of Cancer-Associated FibroblastsSemantic proximity Read

Exploring the diversity of cancer-associated fibroblasts: insights into mechanisms of drug resistanceSemantic proximity Read

Cancer-associated Fibroblasts: Origins, Heterogeneity and Functions in Tumor MicroenvironmentSemantic proximity Read

Constructing a co-culture model of cancer-associated fibroblasts and ovarian cancer organoids and studying mechanisms of drug resistanceSemantic proximity Read

Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21Semantic proximity Read

Recent advances in cancer-associated fibroblast: Biomarkers, signaling pathways, and therapeutic opportunities.Semantic proximity Read

The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas.Semantic proximity Read

Identification of fibroblast subpopulations facilitating to chemotherapy resistance in metastasis of ovarian cancerSemantic proximity Read

Plasticity and Functional Heterogeneity of Cancer-Associated FibroblastsSemantic proximity Read