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Article

Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21

21 Apr 2020

Abstract excerpt

Recent studies indicate that cancer-associated fibroblasts (CAFs) are phenotypically and functionally heterogeneous. However, little is known about CAF subtypes, the roles they play in cancer progression, and molecular mediators of the CAF "state." Here, we identify a novel cell surface pan-CAF marker, CD49e, and demonstrate that two distinct CAF states, distinguished by expression of fibroblast activation...

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PMID: 32434219
DOI: 10.1084/jem.20191094

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