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Article

Functional consistency and molecular evolution: a comprehensive characterization of primary endometrial cancer-associated fibroblasts during in vitro expansion.

Journal of translational medicine - 18 Jun 2026

Bao Lunmin, Wang Ping, Wang Daoming, Li Xiaoduo, Zhang Hailong, Wan Xiufang, Yuan Rui, Xie Nanzi, Lei Ling, Cheng Qihui, Lei Xiaopei, Cao Xian'e, Dai Haibing, Zheng Ting, Jiang Hongmei

Abstract excerpt

BACKGROUND: Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment in endometrial cancer (EC). Primary isolation and culture of CAFs serve as the standard method for investigating their biological roles. However, it remains unclear whether prolonged in vitro culture alters the intrinsic properties of CAFs, potentially affecting experimental reproducibility. This study aims to...

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Identifiers

PMID: 42316290
DOI: 10.1186/s12967-026-08488-1
PMCID: PMC13495234

Genes

CCL2
CXCL1
CXCL2
FAP
IL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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