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Exploring the diversity of cancer-associated fibroblasts: insights into mechanisms of drug resistance

16 May 2024

Abstract excerpt

Introduction: Among the various stromal cell types within the tumor microenvironment, cancer-associated fibroblasts (CAFs) emerge as the predominant constituent, exhibiting a diverse array of oncogenic functions not intrinsic to normal fibroblasts. Their involvement spans across all stages of tumorigenesis, encompassing initiation, progression, and metastasis. Current understanding posits the coexistence of...

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PMID: 38818409
DOI: 10.3389/fcell.2024.1403122

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