Article

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

2020-08-12

Abstract excerpt

<h4>SUMMARY</h4> A safe, effective, and scalable vaccine is urgently needed to halt the ongoing SARS-CoV-2 pandemic. Here, we describe the structure-based design of self-assembling protein nanoparticle immunogens that elicit potent and protective antibody responses against SARS-CoV-2 in mice. The nanoparticle vaccines display 60 copies of the SARS-CoV-2 spike (S) glycoprotein receptor-binding domain (RBD) in a hi...

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Literature Corpus work: 28082d81-32fe-525e-9f3c-7fa2efce9ead
DOI: 10.1101/2020.08.11.247395

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