Article

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

2020-06-11

Abstract excerpt

<h4>Summary</h4> A SARS-CoV-2 vaccine is needed to control the global COVID-19 public health crisis. Atomic-level structures directed the application of prefusion-stabilizing mutations that improved expression and immunogenicity of betacoronavirus spike proteins. Using this established immunogen design, the release of SARS-CoV-2 sequences triggered immediate rapid manufacturing of an mRNA vaccine expressing the p...

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Literature Corpus work: d66b9fd7-6e97-5a4d-b0cc-1043115220af
DOI: 10.1101/2020.06.11.145920

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