Article

Computationally designed mRNA-launched protein nanoparticle vaccines

2024-07-23

Abstract excerpt

Both protein nanoparticle and mRNA vaccines were clinically de-risked during the COVID-19 pandemic. These vaccine modalities have complementary strengths: antigen display on protein nanoparticles can enhance the magnitude, quality, and durability of antibody responses, while mRNA vaccines can be rapidly manufactured and elicit antigen-specific CD4 and CD8 T cells. Here we leverage a computationally designed icosah...

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Literature Corpus work: cbed9dd0-5fa8-5c13-9871-e05536ce3856
DOI: 10.1101/2024.07.22.604655

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