Article

Circulating miRNA Signatures in Early-Stage Huntington’s Disease

2023-01-12

Abstract excerpt

<title>Abstract</title> <p>Huntington’s Disease (HD) is a neurodegenerative disorder caused by the expansion of CAG repeats on exon 1 of the huntingtin (<italic>htt)</italic> gene. This mutation results in the expression of an aberrant protein, mutant HTT, which sets in place a cascade of events that eventually leads to neuronal death within the basal ganglia and cerebral cortex. MicroRNAs (miRNAs) are a class of...

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Literature Corpus work: 6c5dc219-f29c-5d8f-b58e-d5e63b80a026
DOI: 10.21203/rs.3.rs-2440808/v1

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