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Article

Small RNAs in plasma extracellular vesicles define biomarkers of premanifest changes in Huntington's disease.

Journal of extracellular vesicles - 1 Oct 2024

Herrero-Lorenzo Marina, Pérez-Pérez Jesús, Escaramís Georgia, Martínez-Horta Saül, Pérez-González Rocío, Rivas-Asensio Elisa, Kulisevsky Jaime, Gámez-Valero Ana, Martí Eulàlia

Abstract excerpt

Despite the advances in the understanding of Huntington's disease (HD), there is a need for molecular biomarkers to categorize mutation carriers during the preclinical stage of the disease preceding functional decline. Small RNAs (sRNAs) are a promising source of biomarkers since their expression levels are highly sensitive to pathobiological processes. Here, using an optimized method for plasma extracellular...

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PMID: 39377487
DOI: 10.1002/jev2.12522
PMCID: PMC11633361

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