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The Emerging Role of microRNAs in Polyglutamine Diseases

19 Jun 2019

Abstract excerpt

MicroRNAs (miRNAs) are small non-coding molecules that regulate a large amount of post-transcriptional repressor genes by recognizing semi-complementary target sequences that are normally located in the 3' UTR of the mRNA. Altered expression of miRNA has been related to several pathological processes, including polyglutamine (Poly Q) diseases. Specific expression patterns in the circulating fluids and brain...

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PMID: 31275113
DOI: 10.3389/fnmol.2019.00156

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