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Article

MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study

27 Dec 2017

Abstract excerpt

OBJECTIVE: To investigate the feasibility of microRNA (miRNA) levels in CSF as biomarkers for prodromal Huntington disease (HD). METHODS: miRNA levels were measured in CSF from 60 PREDICT-HD study participants using the HTG protocol. Using a CAG-Age Product score, 30 prodromal HD participants were selected based on estimated probability of imminent clinical diagnosis of HD (i.e., low, medium, high; n = 10/group)....

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PMID: 29282329
DOI: 10.1212/wnl.0000000000004844

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