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Article

MicroRNA editing patterns in Huntington's disease.

Scientific reports - 24 Feb 2022

Guo Shiyong, Yang Jun, Jiang Bingbing, Zhou Nan, Ding Hao, Zhou Guangchen, Wu Shuai, Suo Angbaji, Wu Xingwang, Xie Wenping, Li Wanran, Liu Yulong, Deng Wei, Zheng Yun

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disease. MicroRNAs (miRNAs) are small non-coding RNAs that mediate post-transcriptional regulation of target genes. Although miRNAs are extensively edited in human brains, the editome of miRNAs in brains of HD patients is largely unknown. By analyzing the small RNA sequencing profiles of brain tissues of 28 HD patients and 83 normal controls, 1182 miRNA editing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35210471
DOI: 10.1038/s41598-022-06970-6
PMCID: PMC8873361

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