Cannabinoid Receptor Signaling is Dependent on Sub-Cellular Location

Abstract excerpt

G protein-coupled receptors (GPCRs) are membrane bound signaling molecules that regulate many aspects of human physiology. Recent advances have demonstrated that GPCR signaling can occur both at the cell surface and internal cellular membranes. Our findings suggest that cannabinoid receptor 1 (CB1) signaling is highly dependent on its subcellular location. We find that intracellular CB1 receptors predominantly cou...

Topics

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• Allosteric Regulation
• Axons
• Indoles
• Intracellular Space
• Molecular Conformation
• Piperidines
• Receptor, Cannabinoid, CB1
• Receptors, G-Protein-Coupled

Identifiers and source

Literature Corpus work

6c483fd3-d660-548a-bfd7-7460e7b2dcb4

DOI

10.1101/2024.03.21.586146