Article
Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling.
British journal of pharmacology - 1 Apr 2012
Oddi Sergio, Dainese Enrico, Sandiford Simone, Fezza Filomena, Lanuti Mirko, Chiurchiù Valerio, Totaro Antonio, Catanzaro Giuseppina, Barcaroli Daniela, De Laurenzi Vincenzo, Centonze Diego, Mukhopadhyay Somnath, Selent Jana, Howlett Allyn C, Maccarrone Mauro
Abstract excerpt
BACKGROUND AND PURPOSE: The CB(1) cannabinoid receptor is regulated by its association with membrane microdomains such as lipid rafts. Here, we investigated the role of palmitoylation of the CB(1) receptor by analysing the functional consequences of site-specific mutation of Cys(415) , the likely site of palmitoylation at the end of helix 8, in terms of membrane association, raft targeting and signalling....
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