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Cannabinoid CB2 receptor orthologues; in vitro function and perspectives for preclinical to clinical translation

24 Jun 2023

Abstract excerpt

Abstract Cannabinoid CB2 receptor agonists are in development as therapeutic agents, including for immune modulation and pain relief. Despite promising results in rodent preclinical studies, efficacy in human clinical trials has been marginal to date. Fundamental differences in ligand engagement and signalling responses between the human CB2 receptor and preclinical model species orthologues may contribute to...

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PMID: 37349984
DOI: 10.1111/bph.16172

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